ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation

Inner cell Mass (ICM) specification into epiblast (Epi) and primitive endoderm (PrE) is an asynchronous and progressive process taking place between E3.0 to E3.75 under the control of the Fibroblast Growth Factor (FGF)/Extracellular signal-Regulated Kinase (ERK) signaling pathway. Here, we have anal...

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Опубликовано в: :Sci Rep
Главные авторы: Bessonnard, Sylvain, Coqueran, Sabrina, Vandormael-Pournin, Sandrine, Dufour, Alexandre, Artus, Jérôme, Cohen-Tannoudji, Michel
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612930/
https://ncbi.nlm.nih.gov/pubmed/28947813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12120-0
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