ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation

Inner cell Mass (ICM) specification into epiblast (Epi) and primitive endoderm (PrE) is an asynchronous and progressive process taking place between E3.0 to E3.75 under the control of the Fibroblast Growth Factor (FGF)/Extracellular signal-Regulated Kinase (ERK) signaling pathway. Here, we have anal...

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Publicado en:Sci Rep
Autores principales: Bessonnard, Sylvain, Coqueran, Sabrina, Vandormael-Pournin, Sandrine, Dufour, Alexandre, Artus, Jérôme, Cohen-Tannoudji, Michel
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group UK 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612930/
https://ncbi.nlm.nih.gov/pubmed/28947813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12120-0
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