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ICM conversion to epiblast by FGF/ERK inhibition is limited in time and requires transcription and protein degradation

Inner cell Mass (ICM) specification into epiblast (Epi) and primitive endoderm (PrE) is an asynchronous and progressive process taking place between E3.0 to E3.75 under the control of the Fibroblast Growth Factor (FGF)/Extracellular signal-Regulated Kinase (ERK) signaling pathway. Here, we have anal...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Bessonnard, Sylvain, Coqueran, Sabrina, Vandormael-Pournin, Sandrine, Dufour, Alexandre, Artus, Jérôme, Cohen-Tannoudji, Michel
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5612930/
https://ncbi.nlm.nih.gov/pubmed/28947813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12120-0
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