Metformin selectively targets redox control of complex I energy transduction

Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that are likely to account for this difference. In pri...

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Vydáno v:Redox Biol
Hlavní autoři: Cameron, Amy R., Logie, Lisa, Patel, Kashyap, Erhardt, Stefan, Bacon, Sandra, Middleton, Paul, Harthill, Jean, Forteath, Calum, Coats, Josh T., Kerr, Calum, Curry, Heather, Stewart, Derek, Sakamoto, Kei, Repiščák, Peter, Paterson, Martin J., Hassinen, Ilmo, McDougall, Gordon, Rena, Graham
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609876/
https://ncbi.nlm.nih.gov/pubmed/28942196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.08.018
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