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Metformin selectively targets redox control of complex I energy transduction
Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that are likely to account for this difference. In pri...
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| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2018-04-01
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| Colecção: | Redox Biology |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2213231717304779 |
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