Metformin selectively targets redox control of complex I energy transduction

Many guanide-containing drugs are antihyperglycaemic but most exhibit toxicity, to the extent that only the biguanide metformin has enjoyed sustained clinical use. Here, we have isolated unique mitochondrial redox control properties of metformin that are likely to account for this difference. In pri...

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Библиографические подробности
Опубликовано в: :Redox Biol
Главные авторы: Cameron, Amy R., Logie, Lisa, Patel, Kashyap, Erhardt, Stefan, Bacon, Sandra, Middleton, Paul, Harthill, Jean, Forteath, Calum, Coats, Josh T., Kerr, Calum, Curry, Heather, Stewart, Derek, Sakamoto, Kei, Repiščák, Peter, Paterson, Martin J., Hassinen, Ilmo, McDougall, Gordon, Rena, Graham
Формат: Artigo
Язык:Inglês
Опубликовано: Elsevier 2017
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609876/
https://ncbi.nlm.nih.gov/pubmed/28942196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2017.08.018
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