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Crosslinking of DNA-linked ligands to target proteins for enrichment from DNA-encoded libraries()

Achieving sufficient enrichment of ligands from DNA-encoded libraries for detection can be difficult, particularly for low affinity ligands within highly complex libraries. To address this challenge, we present an approach for crosslinking DNA-linked ligands to target proteins using electrophilic or...

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Bibliografiske detaljer
Udgivet i:Medchemcomm
Main Authors: Denton, Kyle E., Krusemark, Casey J.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5609701/
https://ncbi.nlm.nih.gov/pubmed/28948007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/C6MD00288A
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