Quantitative Comparison of Enrichment from DNA-Encoded Chemical Library Selections

[Image: see text] DNA-encoded chemical libraries (DELs) provide a high-throughput and cost-effective route for screening billions of unique molecules for binding affinity for diverse protein targets. Identifying candidate compounds from these libraries involves affinity selection, DNA sequencing, an...

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Publicat a:ACS Comb Sci
Autors principals: Faver, John C., Riehle, Kevin, Lancia, David R., Milbank, Jared B. J., Kollmann, Christopher S., Simmons, Nicholas, Yu, Zhifeng, Matzuk, Martin M.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372980/
https://ncbi.nlm.nih.gov/pubmed/30672692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscombsci.8b00116
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