Developing Antineoplastic Agents that Targeting Peroxisomal Enzymes: Cytisine-linked Isoflavonoids as Inhibitors of Hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4)

Cytisine-linked isoflavonoids (CLIFs) inhibited PC-3 prostate and LS174T colon cancer cell proliferation by inhibiting a peroxisomal bifunctional enzyme. A pull-down assay using a biologically active, biotin-modified CLIF identified the target of these agents as the bifunctional, peroxisomal enzyme,...

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Enregistré dans:
Détails bibliographiques
Publié dans:Org Biomol Chem
Auteurs principaux: Frasinyuk, Mykhaylo S., Zhang, Wen, Wyrebek, Przemyslaw, Yu, Tianxin, Xu, Xuehe, Sviripa, Vitaliy M., Bondarenko, Svitlana P., Xie, Yanqi, Ngo, Huy X., Morris, Andrew J., Mohler, James L., Fiandalo, Michael V., Watt, David S., Liu, Chunming
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607111/
https://ncbi.nlm.nih.gov/pubmed/28868548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob01584d
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