Developing Antineoplastic Agents that Targeting Peroxisomal Enzymes: Cytisine-linked Isoflavonoids as Inhibitors of Hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4)

Cytisine-linked isoflavonoids (CLIFs) inhibited PC-3 prostate and LS174T colon cancer cell proliferation by inhibiting a peroxisomal bifunctional enzyme. A pull-down assay using a biologically active, biotin-modified CLIF identified the target of these agents as the bifunctional, peroxisomal enzyme,...

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Detalhes bibliográficos
Publicado no:Org Biomol Chem
Main Authors: Frasinyuk, Mykhaylo S., Zhang, Wen, Wyrebek, Przemyslaw, Yu, Tianxin, Xu, Xuehe, Sviripa, Vitaliy M., Bondarenko, Svitlana P., Xie, Yanqi, Ngo, Huy X., Morris, Andrew J., Mohler, James L., Fiandalo, Michael V., Watt, David S., Liu, Chunming
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607111/
https://ncbi.nlm.nih.gov/pubmed/28868548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob01584d
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