Developing Antineoplastic Agents that Targeting Peroxisomal Enzymes: Cytisine-linked Isoflavonoids as Inhibitors of Hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4)

Cytisine-linked isoflavonoids (CLIFs) inhibited PC-3 prostate and LS174T colon cancer cell proliferation by inhibiting a peroxisomal bifunctional enzyme. A pull-down assay using a biologically active, biotin-modified CLIF identified the target of these agents as the bifunctional, peroxisomal enzyme,...

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Pubblicato in:Org Biomol Chem
Autori principali: Frasinyuk, Mykhaylo S., Zhang, Wen, Wyrebek, Przemyslaw, Yu, Tianxin, Xu, Xuehe, Sviripa, Vitaliy M., Bondarenko, Svitlana P., Xie, Yanqi, Ngo, Huy X., Morris, Andrew J., Mohler, James L., Fiandalo, Michael V., Watt, David S., Liu, Chunming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607111/
https://ncbi.nlm.nih.gov/pubmed/28868548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob01584d
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