Developing Antineoplastic Agents that Targeting Peroxisomal Enzymes: Cytisine-linked Isoflavonoids as Inhibitors of Hydroxysteroid 17-beta-dehydrogenase-4 (HSD17B4)

Cytisine-linked isoflavonoids (CLIFs) inhibited PC-3 prostate and LS174T colon cancer cell proliferation by inhibiting a peroxisomal bifunctional enzyme. A pull-down assay using a biologically active, biotin-modified CLIF identified the target of these agents as the bifunctional, peroxisomal enzyme,...

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Bibliografiska uppgifter
I publikationen:Org Biomol Chem
Huvudupphovsmän: Frasinyuk, Mykhaylo S., Zhang, Wen, Wyrebek, Przemyslaw, Yu, Tianxin, Xu, Xuehe, Sviripa, Vitaliy M., Bondarenko, Svitlana P., Xie, Yanqi, Ngo, Huy X., Morris, Andrew J., Mohler, James L., Fiandalo, Michael V., Watt, David S., Liu, Chunming
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5607111/
https://ncbi.nlm.nih.gov/pubmed/28868548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7ob01584d
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