Antineoplastic Isoflavonoids Derived from Intermediate ortho-Quinone Methides Generated from Mannich Bases

The regioselective condensations of various 7-hydroxyisoflavonoids with bis(N,N-dimethylamino)methane in a Mannich reaction provided C-8 N,N-dimethylaminomethyl-substituted isoflavonoids in good yield. Similar condensations of 7-hydroxy-8-methylisoflavonoids led to the C-6 substituted analogs. Therm...

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Publicado no:ChemMedChem
Main Authors: Frasinyuk, Mykhaylo S., Mrug, Galyna P., Bondarenko, Svitlana P., Khilya, Volodymyr P., Sviripa, Vitaliy M., Syrotchuk, Oleksandr A., Zhang, Wen, Cai, Xianfeng, Fiandalo, Michael V., Mohler, James L., Liu, Chunming, Watt, David S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818953/
https://ncbi.nlm.nih.gov/pubmed/26889756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600008
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