Antineoplastic Isoflavonoids Derived from Intermediate ortho-Quinone Methides Generated from Mannich Bases

The regioselective condensations of various 7-hydroxyisoflavonoids with bis(N,N-dimethylamino)methane in a Mannich reaction provided C-8 N,N-dimethylaminomethyl-substituted isoflavonoids in good yield. Similar condensations of 7-hydroxy-8-methylisoflavonoids led to the C-6 substituted analogs. Therm...

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Publié dans:ChemMedChem
Auteurs principaux: Frasinyuk, Mykhaylo S., Mrug, Galyna P., Bondarenko, Svitlana P., Khilya, Volodymyr P., Sviripa, Vitaliy M., Syrotchuk, Oleksandr A., Zhang, Wen, Cai, Xianfeng, Fiandalo, Michael V., Mohler, James L., Liu, Chunming, Watt, David S.
Format: Artigo
Langue:Inglês
Publié: 2016
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4818953/
https://ncbi.nlm.nih.gov/pubmed/26889756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.201600008
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