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Endoplasmic reticulum stress and eIF2α phosphorylation: The Achilles heel of pancreatic β cells

BACKGROUND: Pancreatic β cell dysfunction and death are central in the pathogenesis of most if not all forms of diabetes. Understanding the molecular mechanisms underlying β cell failure is important to develop β cell protective approaches. SCOPE OF REVIEW: Here we review the role of endoplasmic ret...

詳細記述

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書誌詳細
出版年:Mol Metab
主要な著者: Cnop, Miriam, Toivonen, Sanna, Igoillo-Esteve, Mariana, Salpea, Paraskevi
フォーマット: Artigo
言語:Inglês
出版事項: Elsevier 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605732/
https://ncbi.nlm.nih.gov/pubmed/28951826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmet.2017.06.001
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