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Discovery of a benzamide derivative that protects pancreatic β-cells against endoplasmic reticulum stress

Endoplasmic reticulum (ER) stress-mediated pancreatic insulin-producing β-cell dysfunction and death are critical elements in the onset and progression of both type 1 and type 2 diabetes. Here, through cell-based high throughput screening we identified benzamide derivatives as a novel class of β-cel...

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Bibliografiske detaljer
Udgivet i:J Med Chem
Main Authors: Duan, Hongliang, Li, Yu, Arora, Daleep, Xu, Depeng, Lim, Hui-Ying, Wang, Weidong
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5605278/
https://ncbi.nlm.nih.gov/pubmed/28696115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b00435
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