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Discovery, Synthesis and Evaluation of 2,4-diaminoquinazolines as a Novel Class of Pancreatic β Cell-Protective Agents against Endoplasmic Reticulum (ER) Stress

Pancreatic insulin-producing β-cell dysfunction and death plays central roles in the onset and progression of both type 1 and type 2 diabetes. Current antidiabetic drugs cannot halt the ongoing progression of β-cell dysfunction and death. In diabetes, a major cause for the decline in β cell function...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Duan, Hongliang, Lee, Jae Wook, Moon, Sung Won, Arora, Daleep, Li, Yu, Lim, Hui-Ying, Wang, Weidong
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5180602/
https://ncbi.nlm.nih.gov/pubmed/27505441
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00041
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