Anticancer efficacy of the hypoxia‐activated prodrug evofosfamide is enhanced in combination with proapoptotic receptor agonists against osteosarcoma

Tumor hypoxia is a major cause of treatment failure for a variety of malignancies. However, hypoxia also leads to treatment opportunities as demonstrated by the development of compounds that target regions of hypoxia within tumors. Evofosfamide is a hypoxia‐activated prodrug that is created by linki...

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Detalhes bibliográficos
Publicado no:Cancer Med
Main Authors: Liapis, Vasilios, Zysk, Aneta, DeNichilo, Mark, Zinonos, Irene, Hay, Shelley, Panagopoulos, Vasilios, Shoubridge, Alexandra, Difelice, Christopher, Ponomarev, Vladimir, Ingman, Wendy, Atkins, Gerald J., Findlay, David M., Zannettino, Andrew C. W., Evdokiou, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Cancer Prevention
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5603834/
https://ncbi.nlm.nih.gov/pubmed/28799237
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cam4.1115
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