Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer

Osteoprotegerin (OPG) is a secreted member of the TNF receptor superfamily, which binds to the receptor activator of nuclear factor κB ligand (RANKL) and inhibits osteoclast activity and bone resorption. Systemic administration of recombinant OPG was previously shown to inhibit tumor growth in bone...

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Main Authors: ZINONOS, IRENE, LUO, KE-WANG, LABRINIDIS, AGATHA, LIAPIS, VASILIOS, HAY, SHELLEY, PANAGOPOULOS, VASILIOS, DENICHILO, MARK, KO, CHUN-HAY, YUE, GRACE GAR-LEE, LAU, CLARA BIK-SAN, INGMAN, WENDY, PONOMAREV, VLADIMIR, ATKINS, GERALD J., FINDLAY, DAVID M., ZANNETTINO, ANDREW C.W., EVDOKIOU, ANDREAS
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091969/
https://ncbi.nlm.nih.gov/pubmed/24865346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2468
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