Pharmacologic inhibition of bone resorption prevents cancer-induced osteolysis but enhances soft tissue metastasis in a mouse model of osteolytic breast cancer

Osteoprotegerin (OPG) is a secreted member of the TNF receptor superfamily, which binds to the receptor activator of nuclear factor κB ligand (RANKL) and inhibits osteoclast activity and bone resorption. Systemic administration of recombinant OPG was previously shown to inhibit tumor growth in bone...

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Autori principali: ZINONOS, IRENE, LUO, KE-WANG, LABRINIDIS, AGATHA, LIAPIS, VASILIOS, HAY, SHELLEY, PANAGOPOULOS, VASILIOS, DENICHILO, MARK, KO, CHUN-HAY, YUE, GRACE GAR-LEE, LAU, CLARA BIK-SAN, INGMAN, WENDY, PONOMAREV, VLADIMIR, ATKINS, GERALD J., FINDLAY, DAVID M., ZANNETTINO, ANDREW C.W., EVDOKIOU, ANDREAS
Natura: Artigo
Lingua:Inglês
Pubblicazione: D.A. Spandidos 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4091969/
https://ncbi.nlm.nih.gov/pubmed/24865346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/ijo.2014.2468
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