HYPOXIA-ACTIVATED PRO-DRUG TH-302 EXHIBITS POTENT TUMOUR SUPPRESSIVE ACTIVITY AND COOPERATES WITH CHEMOTHERAPY AGAINST OSTEOSARCOMA

Tumour hypoxia is a major cause of treatment failure for a variety of malignancies. However, tumour hypoxia also offers treatment opportunities, exemplified by the development compounds that target hypoxic regions within tumours. TH-302 is a pro-drug created by the conjugation of 2-nitroimidazole to...

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Detalhes bibliográficos
Publicado no:Cancer Lett
Main Authors: Liapis, Vasilios, Labrinidis, Agatha, Zinonos, Irene, Hay, Shelley, Ponomarev, Vladimir, Panagopoulos, Vasilios, DeNichilo, Mark, Ingman, Wendy, Atkins, Gerald J., Findlay, David M., Zannettino, Andrew CW., Evdokiou, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4574867/
https://ncbi.nlm.nih.gov/pubmed/25444931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2014.11.020
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