Accelerated Systemic Autoimmunity in the Absence of Somatic Hypermutation in 564Igi: A Mouse Model of Systemic Lupus with Knocked-In Heavy and Light Chain Genes

564Igi mice have knocked-in immunoglobulin (Ig) heavy (H) and light (L) chain genes that encode an autoantibody recognizing RNA. Previously, we showed that these mice produce pathogenic IgG autoantibodies when activation-induced deaminase (AID) is expressed in pre-B and immature B cells but not when...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: McDonald, Gabrielle, Medina, Carlos O., Pilichowska, Monika, Kearney, John F., Shinkura, Reiko, Selsing, Erik, Wortis, Henry H., Honjo, Tasuku, Imanishi-Kari, Thereza
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601273/
https://ncbi.nlm.nih.gov/pubmed/28955333
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2017.01094
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