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Reviving the guardian of the genome: small molecule activators of p53

The tumor suppressor p53 is one of the most important proteins for protection of genomic stability and cancer prevention. Cancers often inactivate it by either mutating its gene or disabling its function. Thus, activating p53 becomes an attractive approach for the development of molecule-based anti-...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Pharmacol Ther
Prif Awduron: Nguyen, Daniel, Liao, Wenjuan, Zeng, Shelya X., Lu, Hua
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5601031/
https://ncbi.nlm.nih.gov/pubmed/28351719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pharmthera.2017.03.013
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