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A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
Although ∼50% of all types of human cancers harbour wild-type TP53, this p53 tumour suppressor is often deactivated through a concerted action by its abnormally elevated suppressors, MDM2, MDMX or SIRT1. Here, we report a novel small molecule Inauhzin (INZ) that effectively reactivates p53 by inhibi...
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| Hoofdauteurs: | , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
WILEY-VCH Verlag
2012
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376857/ https://ncbi.nlm.nih.gov/pubmed/22331558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100211 |
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