A carregar...
A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
Although ∼50% of all types of human cancers harbour wild-type TP53, this p53 tumour suppressor is often deactivated through a concerted action by its abnormally elevated suppressors, MDM2, MDMX or SIRT1. Here, we report a novel small molecule Inauhzin (INZ) that effectively reactivates p53 by inhibi...
Na minha lista:
| Main Authors: | , , , , , , , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
WILEY-VCH Verlag
2012
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3376857/ https://ncbi.nlm.nih.gov/pubmed/22331558 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100211 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|