A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53

Although ∼50% of all types of human cancers harbour wild-type TP53, this p53 tumour suppressor is often deactivated through a concerted action by its abnormally elevated suppressors, MDM2, MDMX or SIRT1. Here, we report a novel small molecule Inauhzin (INZ) that effectively reactivates p53 by inhibi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Zhang, Qi, Zeng, Shelya X, Zhang, Yu, Zhang, Yiwei, Ding, Derong, Ye, Qizhuang, Meroueh, Samy O, Lu, Hua
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: WILEY-VCH Verlag 2012
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3376857/
https://ncbi.nlm.nih.gov/pubmed/22331558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201100211
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