Hormetic potential of methylglyoxal, a side-product of glycolysis, in switching tumours from growth to death

Metabolic reprogramming toward aerobic glycolysis unavoidably favours methylglyoxal (MG) and advanced glycation end products (AGEs) formation in cancer cells. MG was initially considered a highly cytotoxic molecule with potential anti-cancer value. However, we have recently demonstrated that MG enha...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Nokin, Marie-Julie, Durieux, Florence, Bellier, Justine, Peulen, Olivier, Uchida, Koji, Spiegel, David A., Cochrane, James R., Hutton, Craig A., Castronovo, Vincent, Bellahcène, Akeila
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5600983/
https://ncbi.nlm.nih.gov/pubmed/28916747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-12119-7
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