Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer

BACKGROUND: Elevated aerobic glycolysis rate is a biochemical alteration associated with malignant transformation and cancer progression. This metabolic shift unavoidably generates methylglyoxal (MG), a potent inducer of dicarbonyl stress through the formation of advanced glycation end products (AGE...

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書誌詳細
出版年:Breast Cancer Res
主要な著者: Nokin, Marie-Julie, Bellier, Justine, Durieux, Florence, Peulen, Olivier, Rademaker, Gilles, Gabriel, Maude, Monseur, Christine, Charloteaux, Benoit, Verbeke, Lieven, van Laere, Steven, Roncarati, Patrick, Herfs, Michael, Lambert, Charles, Scheijen, Jean, Schalkwijk, Casper, Colige, Alain, Caers, Jo, Delvenne, Philippe, Turtoi, Andrei, Castronovo, Vincent, Bellahcène, Akeila
フォーマット: Artigo
言語:Inglês
出版事項: BioMed Central 2019
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6343302/
https://ncbi.nlm.nih.gov/pubmed/30674353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-018-1095-7
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