Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal (MG) formation in cancer cells. MG mediates the glycation of proteins to form advanced glycation end products (AGEs). We have recently demonstrated that MG-induced AGEs are a common feature of breast cancer. Little i...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Nokin, Marie-Julie, Durieux, Florence, Peixoto, Paul, Chiavarina, Barbara, Peulen, Olivier, Blomme, Arnaud, Turtoi, Andrei, Costanza, Brunella, Smargiasso, Nicolas, Baiwir, Dominique, Scheijen, Jean L, Schalkwijk, Casper G, Leenders, Justine, De Tullio, Pascal, Bianchi, Elettra, Thiry, Marc, Uchida, Koji, Spiegel, David A, Cochrane, James R, Hutton, Craig A, De Pauw, Edwin, Delvenne, Philippe, Belpomme, Dominique, Castronovo, Vincent, Bellahcène, Akeila
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081250/
https://ncbi.nlm.nih.gov/pubmed/27759563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19375
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