Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal (MG) formation in cancer cells. MG mediates the glycation of proteins to form advanced glycation end products (AGEs). We have recently demonstrated that MG-induced AGEs are a common feature of breast cancer. Little i...

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Foilsithe in:eLife
Main Authors: Nokin, Marie-Julie, Durieux, Florence, Peixoto, Paul, Chiavarina, Barbara, Peulen, Olivier, Blomme, Arnaud, Turtoi, Andrei, Costanza, Brunella, Smargiasso, Nicolas, Baiwir, Dominique, Scheijen, Jean L, Schalkwijk, Casper G, Leenders, Justine, De Tullio, Pascal, Bianchi, Elettra, Thiry, Marc, Uchida, Koji, Spiegel, David A, Cochrane, James R, Hutton, Craig A, De Pauw, Edwin, Delvenne, Philippe, Belpomme, Dominique, Castronovo, Vincent, Bellahcène, Akeila
Formáid: Artigo
Teanga:Inglês
Foilsithe: eLife Sciences Publications, Ltd 2016
Ábhair:
Cancer Biology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081250/
https://ncbi.nlm.nih.gov/pubmed/27759563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19375
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