Methylglyoxal, a glycolysis side-product, induces Hsp90 glycation and YAP-mediated tumor growth and metastasis

Metabolic reprogramming toward aerobic glycolysis unavoidably induces methylglyoxal (MG) formation in cancer cells. MG mediates the glycation of proteins to form advanced glycation end products (AGEs). We have recently demonstrated that MG-induced AGEs are a common feature of breast cancer. Little i...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:eLife
Prif Awduron: Nokin, Marie-Julie, Durieux, Florence, Peixoto, Paul, Chiavarina, Barbara, Peulen, Olivier, Blomme, Arnaud, Turtoi, Andrei, Costanza, Brunella, Smargiasso, Nicolas, Baiwir, Dominique, Scheijen, Jean L, Schalkwijk, Casper G, Leenders, Justine, De Tullio, Pascal, Bianchi, Elettra, Thiry, Marc, Uchida, Koji, Spiegel, David A, Cochrane, James R, Hutton, Craig A, De Pauw, Edwin, Delvenne, Philippe, Belpomme, Dominique, Castronovo, Vincent, Bellahcène, Akeila
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: eLife Sciences Publications, Ltd 2016
Pynciau:
Cancer Biology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081250/
https://ncbi.nlm.nih.gov/pubmed/27759563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.19375
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