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Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations
[Image: see text] The cysteine protease enzyme legumain hydrolyzes peptide bonds with high specificity after asparagine and under more acidic conditions after aspartic acid [ E. N. BakerJ. Mol. Biol.1980, 141, 441−4847003158; E. N. Baker; J. Mol. Biol.1977, 111, 207–210859183; J. Drenth; Biochemistr...
Kaydedildi:
| Yayımlandı: | ACS Catal |
|---|---|
| Asıl Yazarlar: | , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American
Chemical Society
2017
|
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5600538/ https://ncbi.nlm.nih.gov/pubmed/28932620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.7b01505 |
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