Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations

Lignende værker

• Structural analyses of Arabidopsis thaliana legumain γ reveal differential recognition and processing of proteolysis and ligation substrates
  af: Zauner, Florian B., et al.
  Udgivet: (2018)
• Structure and Mechanism of an Aspartimide-Dependent Peptide Ligase in Human Legumain**
  af: Dall, Elfriede, et al.
  Udgivet: (2015)
• Mechanisms of Proteolytic Enzymes and Their Inhibition in QM/MM Studies
  af: Elsässer, Brigitta, et al.
  Udgivet: (2021)
• Structural and functional studies of Arabidopsis thaliana legumain beta reveal isoform specific mechanisms of activation and substrate recognition
  af: Dall, Elfriede, et al.
  Udgivet: (2020)
• Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation
  af: Dall, Elfriede, et al.
  Udgivet: (2013)