Assessment of Pharmacokinetic Interactions Between Obeticholic Acid and Caffeine, Midazolam, Warfarin, Dextromethorphan, Omeprazole, Rosuvastatin, and Digoxin in Phase 1 Studies in Healthy Subjects

INTRODUCTION: Obeticholic acid (OCA), a potent and selective farnesoid X receptor agonist, is indicated for the treatment of primary biliary cholangitis (PBC). We investigated the potential drug–drug interaction effect of OCA on metabolic CYP450 enzymes and drug transporters. METHODS: Five phase 1 s...

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Enregistré dans:
Détails bibliographiques
Publié dans:Adv Ther
Auteurs principaux: Edwards, Jeffrey E., Eliot, Lise, Parkinson, Andrew, Karan, Sharon, MacConell, Leigh
Format: Artigo
Langue:Inglês
Publié: Springer Healthcare 2017
Sujets:
Original Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599467/
https://ncbi.nlm.nih.gov/pubmed/28808886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12325-017-0601-0
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