Nicotine Dependence is Associated with Functional Variation in FMO3, an Enzyme that Metabolizes Nicotine in the Brain

A common haplotype of the flavin-containing monooxygenase gene FMO3 is associated with aberrant mRNA splicing, a two-fold reduction in in vivo nicotine N-oxidation and reduced nicotine dependence. Tobacco remains the largest cause of preventable mortality worldwide. CYP2A6, the primary hepatic nicot...

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Pubblicato in:Pharmacogenomics J
Autori principali: Teitelbaum, Aaron M., Murphy, Sharon E., Akk, Gustav, Baker, Timothy B., Germann, Allison, von Weymarn, Linda B., Bierut, Laura J., Goate, Alison, Kharasch, Evan D., Bloom, A. Joseph
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5599305/
https://ncbi.nlm.nih.gov/pubmed/28290528
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/tpj.2016.92
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