HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis

BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells overexpressing heat shock protein B1 (HSPB1 or HSP27) and that this is due to enhance...

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Vydáno v:Cell Death Dis
Hlavní autoři: Kennedy, Donna, Mnich, Katarzyna, Oommen, Deepu, Chakravarthy, Reka, Almeida-Souza, Leonardo, Krols, Michiel, Saveljeva, Svetlana, Doyle, Karen, Gupta, Sanjeev, Timmerman, Vincent, Janssens, Sophie, Gorman, Adrienne M, Samali, Afshin
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596589/
https://ncbi.nlm.nih.gov/pubmed/29048431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.408
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