HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis

BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells overexpressing heat shock protein B1 (HSPB1 or HSP27) and that this is due to enhance...

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發表在:Cell Death Dis
Main Authors: Kennedy, Donna, Mnich, Katarzyna, Oommen, Deepu, Chakravarthy, Reka, Almeida-Souza, Leonardo, Krols, Michiel, Saveljeva, Svetlana, Doyle, Karen, Gupta, Sanjeev, Timmerman, Vincent, Janssens, Sophie, Gorman, Adrienne M, Samali, Afshin
格式: Artigo
語言:Inglês
出版: Nature Publishing Group 2017
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Original Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596589/
https://ncbi.nlm.nih.gov/pubmed/29048431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.408
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