HSPB1 facilitates ERK-mediated phosphorylation and degradation of BIM to attenuate endoplasmic reticulum stress-induced apoptosis

BIM, a pro-apoptotic BH3-only protein, is a key regulator of the intrinsic (or mitochondrial) apoptosis pathway. Here, we show that BIM induction by endoplasmic reticulum (ER) stress is suppressed in rat PC12 cells overexpressing heat shock protein B1 (HSPB1 or HSP27) and that this is due to enhance...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Kennedy, Donna, Mnich, Katarzyna, Oommen, Deepu, Chakravarthy, Reka, Almeida-Souza, Leonardo, Krols, Michiel, Saveljeva, Svetlana, Doyle, Karen, Gupta, Sanjeev, Timmerman, Vincent, Janssens, Sophie, Gorman, Adrienne M, Samali, Afshin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596589/
https://ncbi.nlm.nih.gov/pubmed/29048431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.408
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados