The triterpenoid CDDO-imidazolide ameliorates mouse liver ischemia-reperfusion injury through activating the Nrf2/HO-1 pathway enhanced autophagy

Nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated induction of antioxidants has been implicated to have protective roles in ischemia-reperfusion (I/R) injury in many animal models. However, the in vivo effects of CDDO-imidazole (CDDO-Im) (1-[2-cyano-3-,12-dioxooleana-1,9(11)-dien-28-oyl] i...

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Publicat a:Cell Death Dis
Autors principals: Xu, Dongwei, Chen, Lili, Chen, Xiaosong, Wen, Yankai, Yu, Chang, Yao, Jufang, Wu, Hailong, Wang, Xin, Xia, Qiang, Kong, Xiaoni
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5596572/
https://ncbi.nlm.nih.gov/pubmed/28796242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2017.386
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