Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks, leading to cell lethality. To understand the molecular mechanisms underlying this process, we isolated Xenopus laevis Brca2. We demonstrated that Brca2 protein prevents single-stranded DNA gap accumulation at replic...

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Publié dans:Mol Cell
Auteurs principaux: Kolinjivadi, Arun Mouli, Sannino, Vincenzo, De Antoni, Anna, Zadorozhny, Karina, Kilkenny, Mairi, Técher, Hervé, Baldi, Giorgio, Shen, Rong, Ciccia, Alberto, Pellegrini, Luca, Krejci, Lumir, Costanzo, Vincenzo
Format: Artigo
Langue:Inglês
Publié: Cell Press 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594205/
https://ncbi.nlm.nih.gov/pubmed/28757209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.07.001
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