Wordt geladen...
Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments
Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks, leading to cell lethality. To understand the molecular mechanisms underlying this process, we isolated Xenopus laevis Brca2. We demonstrated that Brca2 protein prevents single-stranded DNA gap accumulation at replic...
Bewaard in:
| Gepubliceerd in: | Mol Cell |
|---|---|
| Hoofdauteurs: | , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Cell Press
2017
|
| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5594205/ https://ncbi.nlm.nih.gov/pubmed/28757209 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.07.001 |
| Tags: |
Voeg label toe
Geen labels, Wees de eerste die dit record labelt!
|