Smarcal1-Mediated Fork Reversal Triggers Mre11-Dependent Degradation of Nascent DNA in the Absence of Brca2 and Stable Rad51 Nucleofilaments

Brca2 deficiency causes Mre11-dependent degradation of nascent DNA at stalled forks, leading to cell lethality. To understand the molecular mechanisms underlying this process, we isolated Xenopus laevis Brca2. We demonstrated that Brca2 protein prevents single-stranded DNA gap accumulation at replic...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Kolinjivadi, Arun Mouli, Sannino, Vincenzo, De Antoni, Anna, Zadorozhny, Karina, Kilkenny, Mairi, Técher, Hervé, Baldi, Giorgio, Shen, Rong, Ciccia, Alberto, Pellegrini, Luca, Krejci, Lumir, Costanzo, Vincenzo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Cell Press 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5594205/
https://ncbi.nlm.nih.gov/pubmed/28757209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2017.07.001
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