Sorafenib targets the mitochondrial electron transport chain complexes and ATP synthase to activate the PINK1–Parkin pathway and modulate cellular drug response

Sorafenib (Nexavar) is a broad-spectrum multikinase inhibitor that proves effective in treating advanced renal-cell carcinoma and liver cancer. Despite its well-characterized mechanism of action on several established cancer-related protein kinases, sorafenib causes variable responses among human tu...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Zhang, Conggang, Liu, Zeyu, Bunker, Eric, Ramirez, Adrian, Lee, Schuyler, Peng, Yinghua, Tan, Aik-Choon, Eckhardt, S. Gail, Chapnick, Douglas A., Liu, Xuedong
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Signal Transduction
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592685/
https://ncbi.nlm.nih.gov/pubmed/28673964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.783175
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