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The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20
A critical function of the PTEN-induced kinase 1 (PINK1)–Parkin pathway is to mediate the clearing of unhealthy or damaged mitochondria via mitophagy. Loss of either PINK1 or Parkin protein expression is associated with Parkinson's disease. Here, using a high-throughput screening approach along...
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| Pubblicato in: | J Biol Chem |
|---|---|
| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Biochemistry and Molecular Biology
2019
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6509500/ https://ncbi.nlm.nih.gov/pubmed/30885942 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006506 |
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