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The plant triterpenoid celastrol blocks PINK1-dependent mitophagy by disrupting PINK1's association with the mitochondrial protein TOM20

A critical function of the PTEN-induced kinase 1 (PINK1)–Parkin pathway is to mediate the clearing of unhealthy or damaged mitochondria via mitophagy. Loss of either PINK1 or Parkin protein expression is associated with Parkinson's disease. Here, using a high-throughput screening approach along...

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Pubblicato in:J Biol Chem
Autori principali: Zhang, Conggang, Wang, Rongchun, Liu, Zeyu, Bunker, Eric, Lee, Schuyler, Giuntini, Michelle, Chapnick, Douglas, Liu, Xuedong
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2019
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6509500/
https://ncbi.nlm.nih.gov/pubmed/30885942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006506
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