The K-Ras effector p38γ MAPK confers intrinsic resistance to tyrosine kinase inhibitors by stimulating EGFR transcription and EGFR dephosphorylation

Mutations in K-Ras and epidermal growth factor receptor (EGFR) are mutually exclusive, but it is not known how K-Ras activation inactivates EGFR, leading to resistance of cancer cells to anti-EGFR therapy. Here, we report that the K-Ras effector p38γ MAPK confers intrinsic resistance to small molecu...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Yin, Ning, Lepp, Adrienne, Ji, Yongsheng, Mortensen, Matthew, Hou, Songwang, Qi, Xiao-Mei, Myers, Charles R., Chen, Guan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5592682/
https://ncbi.nlm.nih.gov/pubmed/28739874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.779488
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