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Phosphorylation and Stabilization of Topoisomerase IIα Protein by p38γ Mitogen-activated Protein Kinase Sensitize Breast Cancer Cells to Its Poisons

Cancer drugs suppress tumor cell growth by inhibiting specific cellular targets. However, most drugs also activate several cellular nonspecific stress pathways, and the implications of these off-target effects are mostly unknown. Here, we report that p38γ, but not p38α, MAPK is specifically activate...

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Autori principali: Qi, Xiaomei, Hou, Songwang, Lepp, Adrienne, Li, Rongshan, Basir, Zainab, Lou, Zhenkun, Chen, Guan
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195563/
https://ncbi.nlm.nih.gov/pubmed/21878638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229260
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