Phosphorylation and Stabilization of Topoisomerase IIα Protein by p38γ Mitogen-activated Protein Kinase Sensitize Breast Cancer Cells to Its Poisons

Cancer drugs suppress tumor cell growth by inhibiting specific cellular targets. However, most drugs also activate several cellular nonspecific stress pathways, and the implications of these off-target effects are mostly unknown. Here, we report that p38γ, but not p38α, MAPK is specifically activate...

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Detalhes bibliográficos
Main Authors: Qi, Xiaomei, Hou, Songwang, Lepp, Adrienne, Li, Rongshan, Basir, Zainab, Lou, Zhenkun, Chen, Guan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3195563/
https://ncbi.nlm.nih.gov/pubmed/21878638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.229260
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