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Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation
Mechanism-based inhibitors (MBIs) are widely employed in chemistry, biology, and medicine due to their exquisite specificity and sustained duration of inhibition. Optimization of MBIs is complicated due to time-dependent inhibition resulting from multi-step inactivation mechanisms. The global kineti...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5590675/ https://ncbi.nlm.nih.gov/pubmed/28510452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b00962 |
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