Učitavanje...
Synthesis of a 3-Amino-2,3-dihydropyrid-4-one and Related Heterocyclic Analogs as Mechanism-Based Inhibitors of BioA, a Pyridoxal-Phosphate (PLP) Dependent Enzyme
Amiclenomycin (ACM) is a chemically unstable antibiotic with selective activity against Mycobacterium tuberculosis (Mtb) due to mechanism-based inhibition of BioA, a pyridoxal 5′-phosphate (PLP) dependent aminotransferase. The first-generation ACM analogue dihydro-2-pyridone 1 is semi-stable and mai...
Spremljeno u:
| Izdano u: | J Org Chem |
|---|---|
| Glavni autori: | , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
|
| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5590672/ https://ncbi.nlm.nih.gov/pubmed/28682613 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.joc.7b00847 |
| Oznake: |
Dodaj oznaku
Bez oznaka, Budi prvi tko označuje ovaj zapis!
|