Nalaganje...
Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation
Mechanism-based inhibitors (MBIs) are widely employed in chemistry, biology, and medicine due to their exquisite specificity and sustained duration of inhibition. Optimization of MBIs is complicated due to time-dependent inhibition resulting from multi-step inactivation mechanisms. The global kineti...
Shranjeno v:
| izdano v: | J Am Chem Soc |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
|
| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5590675/ https://ncbi.nlm.nih.gov/pubmed/28510452 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b00962 |
| Oznake: |
Označite
Brez oznak, prvi označite!
|