Rational Optimization of Mechanism-Based Inhibitors through Determination of the Microscopic Rate Constants of Inactivation

Mechanism-based inhibitors (MBIs) are widely employed in chemistry, biology, and medicine due to their exquisite specificity and sustained duration of inhibition. Optimization of MBIs is complicated due to time-dependent inhibition resulting from multi-step inactivation mechanisms. The global kineti...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:J Am Chem Soc
Hauptverfasser: Eiden, Carter, Maize, Kimberly M., Finzel, Barry C., Lipscomb, John D., Aldrich, Courtney C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590675/
https://ncbi.nlm.nih.gov/pubmed/28510452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b00962
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge