Design, Synthesis, and Preclinical Evaluation of 4-Substituted-5-methyl-furo[2,3-d]pyrimidines as Microtubule Targeting Agents That Are Effective against Multidrug Resistant Cancer Cells

The design, synthesis, and biological evaluations of eight 4-substituted 5-methyl-furo[2,3-d]pyrimidines are reported. Synthesis involved N(4)-alkylation of N-aryl-5-methylfuro[2,3-d]pyrimidin-4-amines, obtained from Ullmann coupling of 4-amino-5-methylfuro[2,3-d]pyrimidine and appropriate aryl iodi...

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Publicado en:J Med Chem
Main Authors: Devambatla, Ravi Kumar Vyas, Namjoshi, Ojas A., Choudhary, Shruti, Hamel, Ernest, Shaffer, Corena V., Rohena, Cristina C., Mooberry, Susan L., Gangjee, Aleem
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5590101/
https://ncbi.nlm.nih.gov/pubmed/27213719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.6b00237
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