Chromatin remodeling system p300-HDAC2-Sin3A is involved in Arginine Starvation-Induced HIF-1α Degradation at the ASS1 promoter for ASS1 Derepression

Argininosuccinate synthetase 1 (ASS1) is the key enzyme that controls biosynthesis of arginine (Arg). ASS1 is silenced in many human malignancies therefore, these tumors require extracellular Arg for growth. The Arg-degrading recombinant protein, pegylated arginine deiminase (ADI-PEG20), has been in...

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Udgivet i:Sci Rep
Main Authors: Tsai, Wen-Bin, Long, Yan, Chang, Jeffrey T., Savaraj, Niramol, Feun, Lynn G., Jung, Manfred, Chen, Helen H. W., Kuo, Macus Tien
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589935/
https://ncbi.nlm.nih.gov/pubmed/28883660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11445-0
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