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Copy number rather than epigenetic alterations are the major dictator of imprinted methylation in tumors
It has been postulated that imprinting aberrations are common in tumors. To understand the role of imprinting in cancer, we have characterized copy-number and methylation in over 280 cancer cell lines and confirm our observations in primary tumors. Imprinted differentially methylated regions (DMRs)...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5589900/ https://ncbi.nlm.nih.gov/pubmed/28883545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00639-9 |
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