Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome

Factor (F) Xa reactive IgG isolated from patients with antiphospholipid syndrome (APS) display higher avidity binding to FXa with greater coagulant effects compared to systemic lupus erythematosus (SLE) non APS IgG. FXa signalling via activation of protease-activated receptors (PAR) leads to increas...

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Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Artim-Esen, Bahar, Smoktunowicz, Natalia, McDonnell, Thomas, Ripoll, Vera M., Pericleous, Charis, Mackie, Ian, Robinson, Eifion, Isenberg, David, Rahman, Anisur, Ioannou, Yiannis, Chambers, Rachel C., Giles, Ian
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2017
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589732/
https://ncbi.nlm.nih.gov/pubmed/28883515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11315-9
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