Factor Xa Mediates Calcium Flux in Endothelial Cells and is Potentiated by Igg From Patients With Lupus and/or Antiphospholipid Syndrome

Factor (F) Xa reactive IgG isolated from patients with antiphospholipid syndrome (APS) display higher avidity binding to FXa with greater coagulant effects compared to systemic lupus erythematosus (SLE) non APS IgG. FXa signalling via activation of protease-activated receptors (PAR) leads to increas...

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Publicado no:Sci Rep
Main Authors: Artim-Esen, Bahar, Smoktunowicz, Natalia, McDonnell, Thomas, Ripoll, Vera M., Pericleous, Charis, Mackie, Ian, Robinson, Eifion, Isenberg, David, Rahman, Anisur, Ioannou, Yiannis, Chambers, Rachel C., Giles, Ian
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5589732/
https://ncbi.nlm.nih.gov/pubmed/28883515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-11315-9
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