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Binding of Antiphospholipid Antibodies to Discontinuous Epitopes on Domain I of Human β(2)-Glycoprotein I: Mutation Studies Including Residues R39 to R43
OBJECTIVE: Pathogenic antiphospholipid antibodies (aPL) bind the self antigen N-terminal domain (domain I) of β(2)-glycoprotein I (β(2)GPI), with residues G40–R43 being important. However, peptides homologous to other regions of domain I have also been shown to bind aPL. Furthermore, there are no pu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2117024/ https://ncbi.nlm.nih.gov/pubmed/17195232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.22306 |
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